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Clinical Trials

Cord blood and cord tissue stem cells are the subject of a significant amount of scientific research in Australia and internationally. There are over 200 registered clinical trials currently underway around the world that are investigating the role stem cells can play in the treatment of various conditions.

Note: Please be aware that cord blood stems cells are currently only approved within Australia for use for haematopoietic reconstitution, and there are currently no approved therapeutic uses for cord tissue stem cells. The following information about currently approved clinical trials and some of the exciting areas of stem cell research is provided for information only, and should not be taken to imply that these clinical trials will result in approved therapeutic treatments.

This page contains 3 tables:
  • Table 1. Clinical Trials where children use their own (autologous) Cord Blood Stem Cells
  • Table 2. Clinical Trials using donor (allogeneic, includes siblings) Cord Blood Stem Cells
  • Table 3. Clinical Trials using donor Mesenchymal Stem Cells (MSC) from Cord Tissue

 

Table 1. Clinical Trials where children use their own (autologous) Cord Blood Stem Cells
Diagnosis Trial stage Trial registry
Acquired Hearing Loss phase 1 NCT01343394
NCT02038972
Autism phase 2
phase 1
NCT01638819
NCT02176317
India
Cerebral Palsy phase 2 NCT01147653
NCT01072370
NCT01988584
Japan
Cerebral Palsy phase 1 Romania
Slovakia
Spain
Encephalopathy (neonatal) phase 1 UMIN000014903
Hypoplastic Left Heart Syndrome (HLHS) phase 1 NCT01445041
NCT01856049
NCT01883076
Neonatal Oxygen Deprivation phase 1 NCT00593242
NCT01506258
NCT01649648
Japan
(pre-/peri-natal) Stroke phase 1 NCT02460484
Traumatic Brain Injury phase 1 NCT01251003
NCT01700166
Type 1 Diabetes phase 1 & 2


phase 0
NCT00989547
NCT00873925
CoRD
ACTRN12613000186752

Table researched by Frances Verter, PhD, Alexey Bersenev, MD PhD, and Pedro Silva Couto, MSc ©2014-2016. Sources of trial data are ClinicalTrials.gov and WHO International Clinical Trials Registry Platform (ICTRP) including: Chinese Clinical Trial Registry (ChiCTR), Korea's Clinical Research Information Service (CRIS), Japan's University hospital Medical Information Network (UMIN), Australian New Zealand Clinical Trials Registry (ANZCTR), etc., plus private communication from lead investigators.

 

Table 2. Clinical Trials using donor (allogeneic, includes siblings) Cord Blood Stem Cells
Diagnosis Trial stage Trial registry
Alzheimer's Disease phase 1/2 NCT02054208
Autism phase 2 NCT02847182
Bronchopulmonary Dysplasia phase 1/2
phase 2
NCT02381366
NCT01897987
Cartilage Repair Approved by
Korean FDA
(Cartistem)
NCT01733186
Cerebral Palsy phase 2 NCT01193660
NCT01528436
NCT01639404
NCT01991145
NCT02025972
Cerebral Palsy phase 1 NCT02599207
ACTRN12616000403437
Israel
Russia
Critical Limb Ischemia phase 1 NCT01019681
KCT0000194
Global development delay
(both autologous and allogeneic)
phase 1 NCT01769716
Graft versus Host Disease (GvHD) phase 1/2 KCT0000389
HIV phase 1 NCT02140944
Spain
Infertility phase 1 ChiCTR-OPC-14005553
NCT02313415
Intraventricular hemorrhage phase 1 NCT02274428
Liver Cirrhosis unknown ChiCTR-TRC-14004411
Neurodegenerative disorders phase 1 NCT02236065
Stroke phase 1 NCT01673932
NCT02397018
NCT02433509
Sweat gland regeneration unknown NCT02304562
Type 1 Diabetes phase 2 NCT01350219
NCT01996228

Table researched by Frances Verter, PhD, Alexey Bersenev, MD PhD, and Pedro Silva Couto, MSc ©2014-2016. Sources of trial data are ClinicalTrials.gov and WHO International Clinical Trials Registry Platform (ICTRP) including: Chinese Clinical Trial Registry (ChiCTR), Korea's Clinical Research Information Service (CRIS), Japan's University hospital Medical Information Network (UMIN), Australian New Zealand Clinical Trials Registry (ANZCTR), etc., plus private communication from lead investigators.

 

Table 3. Clinical Trials using donor Mesenchymal Stem Cells (MSC) from Cord Tissue
Diagnosis Trial registry
Alzheimer's disease NCT01547689
Aplastic anemia NCT02218437
Cardiomyopathy NCT02635464
NCT02439541
Cartilage repair NCT02291926
Cerebral Palsy NCT01929434
ChiCTR-ONC-12003124
Connective tissue diseases ChiCTR-OPB-15005956
Diabetes (Type 2) NCT02302599
ChiCTR-TRC-12002868
Erectile Dysfunction NCT02579148
ChiCTR-OCN-15007041
Liver failure NCT01844063
ChiCTR-ONRC-13004581
NCT02223897
Lung injury NCT02444455
NCT02444858
Lupus ChiCTR-OPC-15006322
Macular Degeneration NCT01226628, press
Multiple Sclerosis NCT01883661
NCT02587715
NCT02237547
Muscular Dystrophy NCT02285673
Myocardial Infarction NCT02323477
Osteoarthritis NCT02237846
NCT02580695
Ovarian failure NCT02644447
Parkinson's disease ChiCTR-ONRC-12002937
Psoriasis NCT02491658
Retinitis pigmentosa NCT01914913
Rheumatoid Arthritis NCT01985464
Sepsis ChiCTR-TRC-14005094
Spinal Cord Injury NCT02481440
NCT02237547
Stroke NCT02378974
ChiCTR-ONRC-12002929
Traumatic optic neuropathy ChiCTR-TRC-14005093
Ulcerative colitis NCT02442037

Table researched by Frances Verter, PhD, Alexey Bersenev, MD PhD, and Pedro Silva Couto, MSc ©2014-2016. Sources of trial data are ClinicalTrials.gov and WHO International Clinical Trials Registry Platform (ICTRP) including: Chinese Clinical Trial Registry (ChiCTR), Korea's Clinical Research Information Service (CRIS), Japan's University hospital Medical Information Network (UMIN), Australian New Zealand Clinical Trials Registry (ANZCTR), etc., plus private communication from lead investigators.

Information supplied courtesy of Parent’s Guide to Cord Blood Foundation